Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix

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Trabecular meshwork and outflow

Core Concepts • iOP elevation results from increased outflow resistance in the outflow pathways: the trabecular meshwork (TM) and the uveoscleral pathway. • steady-state iOP is found in normal eyes where iOP builds up in response to inflow of aqueous humour to the level sufficient to drive fluid across the resistance of the outflow pathways. • in most glaucomatous eyes, the resistance of the ou...

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Dexamethasone induces specific proteins in human trabecular meshwork cells.

Previous studies have demonstrated the presence of high-affinity, glucocorticoid-specific receptors in explants of human outflow tissue and in cultured trabecular meshwork. Glucocorticoid-induced responses of scleral fibroblasts and trabecular meshwork cells were evaluated in this study. Incubation of human trabecular meshwork (HTM) and scleral fibroblast (HS) cells with 10(-7) M dexamethasone ...

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Calf Trabecular Meshwork

Superoxide dismutase and catalase activities have been measured in cell-free extracts of calf trabecular meshwork, and for comparison, in calf iris, retina, lens, liver, and erythrocytes. Gel electrophoresis has been used to identify isozymes of each enzyme. The superoxide dismutase and catalase activities per milligram wet weight of calf trabecular meshwork, 0.184 and 0.884 U/mg wet wt, respec...

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sCD44 internalization in human trabecular meshwork cells.

PURPOSE To determine whether soluble CD44 (sCD44), a likely biomarker of primary open-angle glaucoma (POAG), is internalized in cultured human trabecular meshwork (TM) cells and trafficked to mitochondria. METHODS In vitro, 32-kD sCD44 was isolated from human sera, biotinylated, and dephosphorylated. TM cells were incubated for 1 hour at 4°C with biotinylated albumin (b-albumin), biotin-label...

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Hyaluronan synthase in trabecular meshwork cells.

BACKGROUND/AIMS Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated. METHODS Cultured bovine trabecular meshwork cells (BTMCs) were used. HAS expression in...

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ژورنال

عنوان ژورنال: Investigative Opthalmology & Visual Science

سال: 2015

ISSN: 1552-5783

DOI: 10.1167/iovs.15-16739